Blar i forfatter "Einvik, Christer"

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    • Clinically Relevant Biomarker Discovery in High-Risk Recurrent Neuroblastoma 

      Utnes, Peter; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-11)
      Neuroblastoma is a pediatric cancer of the developing sympathetic nervous system. High-risk neuroblastoma patients typically undergo an initial remission in response to treatment, followed by recurrence of aggressive tumors that have become refractory to further treatment. The need for biomarkers that can select patients not responding well to therapy in an early phase is therefore needed. In this ...

    • Exosome-like extracellular vesicles from MYCN-amplified neuroblastoma cells contain oncogenic miRNAs 

      Haug, Bjørn Helge; Hald, Øyvind; Utnes, Peter; Roth, Sarah A; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      <p><i>Background:</i> In recent years, evidence has accumulated indicating that both normal and cancer cells communicate via the release and delivery of macromolecules packed into extracellular membrane vesicles. <p><i>Materials and Methods:</i> We isolated nano-sized extracellular vesicles from MYCN-amplified neuroblastoma cell lines using ultracentrifugation and exosome precipitation (Exoquick) ...

    • Hsa-miR-323a-3p functions as a tumor suppressor and targets STAT3 in neuroblastoma cells 

      Bhavsar, Swapnil; Olsen, Lotte; Løkke, Cecilie; Koster, Jan; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-24)
      Background: Studies conducted in the last decades have revealed a role for the non-coding microRNAs (miRNAs) in cancer development and progression. Several miRNAs within the chromosome region 14q32, a region commonly deleted in cancers, are associated with poor clinical outcome in the childhood cancer neuroblastoma. We have previously identified miR-323a-3p from this region to be downregulated in ...

    • Hsa-miR-376c-3p targets cyclin D1 and induces G1-cell cycle arrest in neuroblastoma cells 

      Bhavsar, Swapnil Parashram; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-11)
      High‑risk neuroblastoma is the most aggressive form of cancer in children. The estimated survival of children with high‑risk neuroblastoma is 40‑50% compared with low and intermediate risk neuroblastoma, which is >98 and 90‑95%, respectively. In addition, patients with high‑risk neuroblastoma often experience relapse following intensive treatments with standard chemotherapeutic drugs. Therefore ...

    • Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma 

      Hald, Øyvind Holsbø; Olsen, Lotte; Gallo-Oller, Gabriel; Elfman, Lotta Helena Maria; Løkke, Cecilie; Kogner, Per; Sveinbjørnsson, Baldur; Flægstad, Trond; Johnsen, John Inge; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-12)
      Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous ...

    • MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN 

      Roth, Sarah Andrea; Hald, Øyvind Holsbø; Fuchs, Steffen; Løkke, Cecilie; Mikkola, Ingvild; Flægstad, Trond; Schulte, Johannes; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-06)
      Neuroblastoma is the most common diagnosed tumor in infants and the second most common extracranial tumor of childhood. The survival rate of patients with high-risk neuroblastoma is still very low despite intensive multimodal treatments. Therefore, new treatment strategies are needed. In recent years, miRNA-based anticancer therapy has received growing attention. Advances in this novel treatment ...

    • MYCN-regulated miRNAs Inhibit Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma 

      Haug, Bjørn Helge; Henriksen, Jørn Remi; Buechner, Jochen; Kogner, Per; Martinsson, Tommy; Flægstad, Trond; Sveinbjørnsson, Baldur; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The MYCN oncogene is frequently amplified in neuroblastoma. It is one of the most consistent markers of a bad prognosis for this disease. Dickkopf-3 (DKK3) is a secreted protein of the Dickkopf family of Wnt regulators. It functions as a tumor suppressor in a range of cancers, including neuroblastoma. MYCN was recently found to downregulate DKK3 mRNA. In this study, we show that MYCN knockdown in ...

    • Short-term sequence evolution and vertical inheritance of the Naegleria twin-ribozyme group I intron 

      Wikmark, Odd-Gunnar; De Jonckheere, Johan F.; Einvik, Christer; Johansen, Steinar D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2006-05-02)
      Background Ribosomal DNA of several species of the free-living Naegleria amoeba harbors an optional group I intron within the nuclear small subunit ribosomal RNA gene. The intron (Nae.S516) has a complex organization of two ribozyme domains (NaGIR1 and NaGIR2) and a homing endonuclease gene (NaHEG). NaGIR2 is responsible for intron excision, exon ligation, and full-length intron RNA circularization, ...

    • Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma 

      Buechner, Jochen; Tømte, Ellen; Haug, Bjørn Helge; Henriksen, Jørn Remi; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-06-07)
      BACKGROUND: MicroRNAs (miRNAs) regulate expression of many cancer-related genes through posttranscriptional repression of their mRNAs. In this study we investigate the proto-oncogene MYCN as a target for miRNA regulation.<p> <p>METHODS: A luciferase reporter assay was used to investigate software-predicted miRNA target sites in the 30 -untranslated region (30 UTR) of MYCN. The miRNAs were ...

    • Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance 

      Wickström, Malin; Dyberg, Cecilia; Milosevic, Jelena; Einvik, Christer; Calero, Raul; Sveinbjørnsson, Baldur; Sandén, Emma; Darabi, Anna; Siesjö, Peter; Kool, Marcel; Kogner, Per; Baryawno, Ninib; Johnsen, John Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-25)
      The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency. As a different strategy to inhibit MGMT we investigated cellular regulators of MGMT expression in multiple cancers. Here we show a ...